Photodynamics of Corneal Collagen Crosslinking Using UVA- Light Activated Riboflavin
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چکیده
PDT is a procedure using light (often low-power laser light or LED) absorption by the external chemical agents (or photosensitizers) causing photo-chemical reactions in the treated tissues. Many photosensitizers have been developed to match the absorption peaks of light wavelengths ranging from ultraviolet (300-390 nm), visible (400-700 nm) to near-IR (700-950 nm) for applications such as in dentistry, dermatology, ophthalmology and cancer treatments in various parts of human body [1].
منابع مشابه
Effect of complete epithelial debridement before riboflavin-ultraviolet-A corneal collagen crosslinking therapy.
PURPOSE To evaluate the importance of complete epithelial removal before riboflavin-ultraviolet-A (UVA) corneal collagen crosslinking therapy. SETTING School of Optometry and Vision Sciences, Cardiff University, Wales, United Kingdom. METHODS Riboflavin eyedrops were applied at 5-minute intervals for 35 minutes to the anterior corneal surface of 36 porcine eyes (12 with no epithelial trauma...
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PURPOSE To determine intraoperative changes in corneal thickness and outcomes of corneal collagen crosslinking (CXL) using 2 intraoperative regimens: riboflavin-dextran or hypotonic riboflavin. SETTING Cornea and refractive surgery practice, Teaneck, New Jersey, USA. DESIGN Prospective randomized case series. METHODS Eyes with keratoconus or corneal ectasia were treated. All eyes received...
متن کاملNon-destructive mechanical characterisation of UVA/riboflavin crosslinked collagen hydrogels.
AIMS To establish a non-destructive method of characterising the mechanical properties of collagen hydrogels to model corneal tissue and to examine the effect of photochemical crosslinking on their mechanical properties. METHODS Collagen hydrogels were manufactured, submerged in 0.1% riboflavin solution and crosslinked using two UVA tube bulbs with an intensity of between 2.8 and 3.2 mW/cm(2)...
متن کاملProtective Effects of Soluble Collagen during Ultraviolet-A Crosslinking on Enzyme-Mediated Corneal Ectatic Models
Collagen crosslinking is a relatively new treatment for structural disorders of corneal ectasia, such as keratoconus. However, there is a lack of animal models of keratoconus, which has been an obstacle for carefully analyzing the mechanisms of crosslinking and evaluating new therapies. In this study, we treated rabbit eyes with collagenase and chondroitinase enzymes to generate ex vivo corneal...
متن کاملThe Effect of Riboflavin/UVA Collagen Cross-linking Therapy on the Structure and Hydrodynamic Behaviour of the Ungulate and Rabbit Corneal Stroma
PURPOSE To examine the effect of riboflavin/UVA corneal crosslinking on stromal ultrastructure and hydrodynamic behaviour. METHODS One hundred and seventeen enucleated ungulate eyes (112 pig and 5 sheep) and 3 pairs of rabbit eyes, with corneal epithelium removed, were divided into four treatment groups: Group 1 (28 pig, 2 sheep and 3 rabbits) were untreated; Group 2 (24 pig) were exposed to ...
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